Tissue expression of CCRL2 - Summary - The Human Protein Atlas

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CCRL2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CCRL2
Gene description	Chemokine (C-C motif) receptor-like 2
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043238
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION
Gene name	CCRL2 (HGNC Symbol)
Synonyms	ACKR5, CKRX, CRAM-A, CRAM-B, HCR
Description	Chemokine (C-C motif) receptor-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	46407163 - 46412997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121797 (version 83.38)
Entrez gene	9034
UniProt	O00421 (UniProt - Evidence at protein level)
neXtProt	NX_O00421
Antibodypedia	CCRL2 antibodies

PROTEIN BROWSER

CCRL2-001	CCRL2-002	CCRL2-003	CCRL2-004	CCRL2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCRL2-001 ENSP00000349967 ENST00000357392	O00421 [Direct mapping] C-C chemokine receptor-like 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	356 aa 41 kDa	No	7
CCRL2-002 ENSP00000381994 ENST00000399036	O00421 [Direct mapping] C-C chemokine receptor-like 2 B2R8C0 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor-like 2, isoform CRA_a; cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	344 aa 39.5 kDa	No	7
CCRL2-003 ENSP00000383678 ENST00000400882	O00421 [Direct mapping] C-C chemokine receptor-like 2 B2R8C0 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor-like 2, isoform CRA_a; cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	344 aa 39.5 kDa	No	7
CCRL2-004 ENSP00000383677 ENST00000400880	O00421 [Direct mapping] C-C chemokine receptor-like 2 B2R8C0 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor-like 2, isoform CRA_a; cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042379 [chemokine receptor binding] GO:0048020 [CCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	344 aa 39.5 kDa	No	7
CCRL2-005 ENSP00000414957 ENST00000433848	C9JP23 [Direct mapping] C-C chemokine receptor-like 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	217 aa 24.6 kDa	No	5

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.