Cell atlas - LIAS - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LIAS

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	LIAS
Gene description	Lipoic acid synthetase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018842
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the mitochondria.

Main location

Nucleoplasm (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018842	A-431	Nucleoplasm
			Mitochondria
			Cytosol
	HPA018842	U-2 OS	Nucleoplasm
	HPA018842	U-2 OS	Mitochondria
	HPA018842	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	LIAS (HGNC Symbol)
Synonyms	LAS
Description	Lipoic acid synthetase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	39459000 - 39477653
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121897 (version 83.38)
Entrez gene	11019
UniProt	O43766 (UniProt - Evidence at protein level)
neXtProt	NX_O43766
Antibodypedia	LIAS antibodies

PROTEIN BROWSER

LIAS-001	LIAS-002	LIAS-006	LIAS-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIAS-001 ENSP00000261434 ENST00000261434	O43766 [Direct mapping] Lipoyl synthase, mitochondrial A0A024R9W0 [Target identity:100%; Query identity:100%] Lipoyl synthase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0009107 [lipoate biosynthetic process] GO:0009249 [protein lipoylation] GO:0016992 [lipoate synthase activity] GO:0032496 [response to lipopolysaccharide] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	372 aa 41.9 kDa	No	0
LIAS-002 ENSP00000371270 ENST00000381846	O43766 [Direct mapping] Lipoyl synthase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0009107 [lipoate biosynthetic process] GO:0009249 [protein lipoylation] GO:0016992 [lipoate synthase activity] GO:0032496 [response to lipopolysaccharide] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	329 aa 37.1 kDa	No	0
LIAS-006 ENSP00000425580 ENST00000513731	D6RCP8 [Direct mapping] Lipoyl synthase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009107 [lipoate biosynthetic process] GO:0016992 [lipoate synthase activity] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	242 aa 27.5 kDa	No	0
LIAS-008 ENSP00000340676 ENST00000340169	O43766 [Direct mapping] Lipoyl synthase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0009107 [lipoate biosynthetic process] GO:0009249 [protein lipoylation] GO:0016992 [lipoate synthase activity] GO:0032496 [response to lipopolysaccharide] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	322 aa 36.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.