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LIAS

GENERAL INFORMATION

Gene name

 LIAS

Gene description

 Lipoic acid synthetase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA018842 , HPA019076
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018842
HPA019076

GENE INFORMATION

Gene name

 LIAS (HGNC Symbol)

Synonyms

 LAS

Description

 Lipoic acid synthetase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 39459000 - 39477653

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121897 (version 83.38)

Entrez gene

 11019

UniProt

 O43766 (UniProt - Evidence at protein level)

neXtProt

 NX_O43766

Antibodypedia

 LIAS antibodies

PROTEIN BROWSER
LIAS-001
LIAS-002
LIAS-006
LIAS-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIAS-001
ENSP00000261434
ENST00000261434
O43766 [Direct mapping]
Lipoyl synthase, mitochondrial
A0A024R9W0 [Target identity:100%; Query identity:100%]
Lipoyl synthase, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001843 [neural tube closure]
GO:0003824 [catalytic activity]
GO:0005739 [mitochondrion]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0009107 [lipoate biosynthetic process]
GO:0009249 [protein lipoylation]
GO:0016992 [lipoate synthase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
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 372 aa
41.9 kDa 		No 0
LIAS-002
ENSP00000371270
ENST00000381846
O43766 [Direct mapping]
Lipoyl synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005739 [mitochondrion]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0009107 [lipoate biosynthetic process]
GO:0009249 [protein lipoylation]
GO:0016992 [lipoate synthase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
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 329 aa
37.1 kDa 		No 0
LIAS-006
ENSP00000425580
ENST00000513731
D6RCP8 [Direct mapping]
Lipoyl synthase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009107 [lipoate biosynthetic process]
GO:0016992 [lipoate synthase activity]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 242 aa
27.5 kDa 		No 0
LIAS-008
ENSP00000340676
ENST00000340169
O43766 [Direct mapping]
Lipoyl synthase, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005739 [mitochondrion]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0009107 [lipoate biosynthetic process]
GO:0009249 [protein lipoylation]
GO:0016992 [lipoate synthase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 322 aa
36.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.