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Papillary adenocarcinomas of thyroid and several colorectal cancers displayed moderate to strong cytoplasmic positivity. Many squamous cell carcinomas, pancreatic and renal cancers along with a few ovarian and stomach cancers were moderately stained. Remaining malignant cells were weakly stained or negative.
Most malignant cells were negative. A few renal adenocarcinomas displayed moderate to strong immunoreactivity.
GENE INFORMATION
Gene name
HPCA
Synonyms
Description
Hippocalcin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]