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HPCA

GENERAL INFORMATION

Gene name

 HPCA

Gene description

 Hippocalcin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, hippocampus)
FANTOM5:Group enriched (caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA043245 , CAB012340
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hippocampus)

GENE INFORMATION

Gene name

 HPCA

Synonyms

Description

 Hippocalcin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.1

Chromosome location (bp)

 32885994 - 32898441

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121905 (version 83.38)

Entrez gene

 3208

UniProt

 P84074 (UniProt - Evidence at protein level)

neXtProt

 NX_P84074

Antibodypedia

 HPCA antibodies

PROTEIN BROWSER
HPCA-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPCA-001
ENSP00000362566
ENST00000373467
P84074 [Direct mapping]
Neuron-specific calcium-binding protein hippocalcin
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007420 [brain development]
GO:0010518 [positive regulation of phospholipase activity]
GO:0014070 [response to organic cyclic compound]
GO:0019722 [calcium-mediated signaling]
GO:0019900 [kinase binding]
GO:0030424 [axon]
GO:0031283 [negative regulation of guanylate cyclase activity]
GO:0031584 [activation of phospholipase D activity]
GO:0032590 [dendrite membrane]
GO:0032809 [neuronal cell body membrane]
GO:0032839 [dendrite cytoplasm]
GO:0043204 [perikaryon]
GO:0044327 [dendritic spine head]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0048839 [inner ear development]
GO:0060041 [retina development in camera-type eye]
GO:0071257 [cellular response to electrical stimulus]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:1901986 [response to ketamine]
GO:1902065 [response to L-glutamate]
GO:1904009 [cellular response to monosodium glutamate]
GO:1904010 [response to Aroclor 1254]
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 193 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.