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Cell line enhanced (Karpas-707, SCLC-21H, SH-SY5Y)
HPA (normal tissue):
Tissue enhanced (adrenal gland, cerebral cortex)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Distinct cytoplasmic expression in brain, mainly in caudate nucleus, granular layer in cerebellum and in peripheral nerves in pancreas and adrenal gland.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.
Most malignant cells displayed weak to moderate nuclear and occasional cytoplasmic immunoreactivity. Occasional cases of malignant gliomas were strongly stained.
A few cases of urothelial and testicular cancers showed moderate cytoplasmic staining. A single case of carcinoid showed strong positivity. Remaining cancers were weakly stained or negative.