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SV2C

GENERAL INFORMATION

Gene name

 SV2C

Gene description

 Synaptic vesicle glycoprotein 2C

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Group enriched (caudate, hypothalamus)
FANTOM5:Tissue enriched (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in brain, mainly in caudate nucleus, granular layer in cerebellum and in peripheral nerves in pancreas and adrenal gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA040722 , HPA040770
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION

Gene name

 SV2C

Synonyms

Description

 Synaptic vesicle glycoprotein 2C (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q13.3

Chromosome location (bp)

 76083172 - 76353939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122012 (version 83.38)

Entrez gene

 22987

UniProt

 Q496J9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q496J9

Antibodypedia

 SV2C antibodies

PROTEIN BROWSER
SV2C-001
SV2C-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SV2C-001
ENSP00000423541
ENST00000502798
Q496J9 [Direct mapping]
Synaptic vesicle glycoprotein 2C
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
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GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006836 [neurotransmitter transport]
GO:0008021 [synaptic vesicle]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0055085 [transmembrane transport]
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 727 aa
82.3 kDa 		No >9
SV2C-002
ENSP00000316983
ENST00000322285
B3KT41 [Direct mapping]
Synaptic vesicle glycoprotein 2C; cDNA FLJ37598 fis, clone BRCOC2008642, highly similar to Synaptic vesicle glycoprotein 2C
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
 676 aa
77.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.