Expression of XPNPEP2 in cancer - Summary - The Human Protein Atlas

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XPNPEP2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	XPNPEP2
Gene description	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer, stomach cancer)
HPA (cell line):	Cell line enriched (ASC TERT1)
HPA (normal tissue):	Group enriched (duodenum, kidney, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in renal tubules and intestinal glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA000339 , CAB025136 , CAB025269
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000339	CAB025136	CAB025269

GENE INFORMATION
Gene name	XPNPEP2
Synonyms
Description	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (HGNC Symbol)
Entrez gene summary	Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	129738974 - 129769538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122121 (version 83.38)
Entrez gene	7512
UniProt	O43895 (UniProt - Evidence at transcript level)
neXtProt	NX_O43895
Antibodypedia	XPNPEP2 antibodies

PROTEIN BROWSER

XPNPEP2-001	XPNPEP2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XPNPEP2-001 ENSP00000360147 ENST00000371106	O43895 [Direct mapping] Xaa-Pro aminopeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	674 aa 75.6 kDa	Yes	0
XPNPEP2-002 ENSP00000360146 ENST00000371105	Q5JZ40 [Direct mapping] Xaa-Pro aminopeptidase 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	183 aa 20.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.