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NPY

GENERAL INFORMATION

Gene name

 NPY

Gene description

 Neuropeptide Y

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enriched (SH-SY5Y)
HPA (normal tissue):Group enriched (adrenal gland, cerebral cortex, prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in peripheral nerves, prostate, a subset of cells in adrenal gland and a subset of neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA044572 , HPA056798 , CAB016733 , CAB034368
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA044572
HPA056798
CAB016733
CAB034368

GENE INFORMATION

Gene name

 NPY (HGNC Symbol)

Synonyms

 PYY4

Description

 Neuropeptide Y (HGNC Symbol)

Entrez gene summary

 This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Chromosome

 7

Cytoband

 p15.3

Chromosome location (bp)

 24284163 - 24291865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122585 (version 83.38)

Entrez gene

 4852

UniProt

 P01303 (UniProt - Evidence at protein level)

neXtProt

 NX_P01303

Antibodypedia

 NPY antibodies

PROTEIN BROWSER
NPY-001
NPY-002
NPY-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPY-001
ENSP00000242152
ENST00000242152
P01303 [Direct mapping]
Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY
A4D158 [Target identity:100%; Query identity:100%]
Neuropeptide Y; cDNA, FLJ92442, Homo sapiens neuropeptide Y (NPY), mRNA
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0004930 [G-protein coupled receptor activity]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005246 [calcium channel regulator activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005794 [Golgi apparatus]
GO:0006816 [calcium ion transport]
GO:0006928 [movement of cell or subcellular component]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007586 [digestion]
GO:0007610 [behavior]
GO:0007631 [feeding behavior]
GO:0008015 [blood circulation]
GO:0008283 [cell proliferation]
GO:0008343 [adult feeding behavior]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0021954 [central nervous system neuron development]
GO:0021987 [cerebral cortex development]
GO:0031175 [neuron projection development]
GO:0031841 [neuropeptide Y receptor binding]
GO:0032098 [regulation of appetite]
GO:0032100 [positive regulation of appetite]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 97 aa
10.9 kDa 		Yes 0
NPY-002
ENSP00000385282
ENST00000405982
P01303 [Direct mapping]
Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY
A4D158 [Target identity:100%; Query identity:100%]
Neuropeptide Y; cDNA, FLJ92442, Homo sapiens neuropeptide Y (NPY), mRNA
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0004930 [G-protein coupled receptor activity]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005246 [calcium channel regulator activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005794 [Golgi apparatus]
GO:0006816 [calcium ion transport]
GO:0006928 [movement of cell or subcellular component]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007586 [digestion]
GO:0007610 [behavior]
GO:0007631 [feeding behavior]
GO:0008015 [blood circulation]
GO:0008283 [cell proliferation]
GO:0008343 [adult feeding behavior]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0021954 [central nervous system neuron development]
GO:0021987 [cerebral cortex development]
GO:0031175 [neuron projection development]
GO:0031841 [neuropeptide Y receptor binding]
GO:0032098 [regulation of appetite]
GO:0032100 [positive regulation of appetite]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 97 aa
10.9 kDa 		Yes 0
NPY-003
ENSP00000384364
ENST00000407573
P01303 [Direct mapping]
Pro-neuropeptide Y Neuropeptide Y C-flanking peptide of NPY
A4D158 [Target identity:100%; Query identity:100%]
Neuropeptide Y; cDNA, FLJ92442, Homo sapiens neuropeptide Y (NPY), mRNA
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001878 [response to yeast]
GO:0004930 [G-protein coupled receptor activity]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005246 [calcium channel regulator activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006816 [calcium ion transport]
GO:0006928 [movement of cell or subcellular component]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007586 [digestion]
GO:0007610 [behavior]
GO:0007631 [feeding behavior]
GO:0008015 [blood circulation]
GO:0008217 [regulation of blood pressure]
GO:0008283 [cell proliferation]
GO:0008343 [adult feeding behavior]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0021954 [central nervous system neuron development]
GO:0021987 [cerebral cortex development]
GO:0031175 [neuron projection development]
GO:0031841 [neuropeptide Y receptor binding]
GO:0032098 [regulation of appetite]
GO:0032100 [positive regulation of appetite]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 97 aa
10.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.