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AKR1D1

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GENERAL INFORMATION

Gene name

 AKR1D1

Gene description

 Aldo-keto reductase family 1, member D1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enriched (Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA057002
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (approved)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057002 Hep G2 Nucleoplasm Intensity
Cytosol
HPA057002 U-2 OS No staining    
HPA057002 U-251 MG No staining    

GENE INFORMATION

Gene name

 AKR1D1 (HGNC Symbol)

Synonyms

 SRD5B1

Description

 Aldo-keto reductase family 1, member D1 (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 138002324 - 138117986

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122787 (version 83.38)

Entrez gene

 6718

UniProt

 P51857 (UniProt - Evidence at protein level)

neXtProt

 NX_P51857

Antibodypedia

 AKR1D1 antibodies

PROTEIN BROWSER
AKR1D1-001
AKR1D1-002
AKR1D1-006
AKR1D1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1D1-001
ENSP00000402374
ENST00000411726
P51857 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007586 [digestion]
GO:0008206 [bile acid metabolic process]
GO:0008207 [C21-steroid hormone metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030573 [bile acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 285 aa
32.9 kDa 		No 0
AKR1D1-002
ENSP00000242375
ENST00000242375
P51857 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007586 [digestion]
GO:0008206 [bile acid metabolic process]
GO:0008207 [C21-steroid hormone metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030573 [bile acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 326 aa
37.4 kDa 		No 0
AKR1D1-006
ENSP00000389197
ENST00000432161
P51857 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007586 [digestion]
GO:0008206 [bile acid metabolic process]
GO:0008207 [C21-steroid hormone metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030573 [bile acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 290 aa
32.7 kDa 		No 0
AKR1D1-009
ENSP00000397042
ENST00000438242
C9J3U1 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 96 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.