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AKR1D1

GENERAL INFORMATION

Gene name

 AKR1D1

Gene description

 Aldo-keto reductase family 1, member D1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA057002
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057002

GENE INFORMATION

Gene name

 AKR1D1 (HGNC Symbol)

Synonyms

 SRD5B1

Description

 Aldo-keto reductase family 1, member D1 (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 138002324 - 138117986

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122787 (version 83.38)

Entrez gene

 6718

UniProt

 P51857 (UniProt - Evidence at protein level)

neXtProt

 NX_P51857

Antibodypedia

 AKR1D1 antibodies

PROTEIN BROWSER
AKR1D1-001
AKR1D1-002
AKR1D1-006
AKR1D1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1D1-001
ENSP00000402374
ENST00000411726
P51857 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005496 [steroid binding]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007586 [digestion]
GO:0008206 [bile acid metabolic process]
GO:0008207 [C21-steroid hormone metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030573 [bile acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 285 aa
32.9 kDa 		No 0
AKR1D1-002
ENSP00000242375
ENST00000242375
P51857 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007586 [digestion]
GO:0008206 [bile acid metabolic process]
GO:0008207 [C21-steroid hormone metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030573 [bile acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 326 aa
37.4 kDa 		No 0
AKR1D1-006
ENSP00000389197
ENST00000432161
P51857 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005496 [steroid binding]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0007586 [digestion]
GO:0008206 [bile acid metabolic process]
GO:0008207 [C21-steroid hormone metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030573 [bile acid catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 290 aa
32.7 kDa 		No 0
AKR1D1-009
ENSP00000397042
ENST00000438242
C9J3U1 [Direct mapping]
3-oxo-5-beta-steroid 4-dehydrogenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 96 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.