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BICC1

GENERAL INFORMATION

Gene name

 BICC1

Gene description

 BicC family RNA binding protein 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2, RPTEC TERT1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA045212
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045212

GENE INFORMATION

Gene name

 BICC1

Synonyms

Description

 BicC family RNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

Chromosome

 10

Cytoband

 q21.1

Chromosome location (bp)

 58513140 - 58831437

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122870 (version 83.38)

Entrez gene

 80114

UniProt

 Q9H694 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H694

Antibodypedia

 BICC1 antibodies

PROTEIN BROWSER
BICC1-001
BICC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BICC1-001
ENSP00000263103
ENST00000263103
A6NGY7 [Direct mapping]
Protein bicaudal C homolog 1
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 506 aa
53.3 kDa 		No 0
BICC1-002
ENSP00000362993
ENST00000373886
Q9H694 [Direct mapping]
Protein bicaudal C homolog 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0044822 [poly(A) RNA binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 974 aa
104.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.