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ZWINT

GENERAL INFORMATION

Gene name

 ZWINT

Gene description

 ZW10 interacting kinetochore protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression which often had a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA005757 , HPA022264 , CAB033926
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA005757
HPA022264
CAB033926

GENE INFORMATION

Gene name

 ZWINT (HGNC Symbol)

Synonyms

 KNTC2AP, SIP30

Description

 ZW10 interacting kinetochore protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q21.1

Chromosome location (bp)

 56357228 - 56361275

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122952 (version 83.38)

Entrez gene

 11130

UniProt

 O95229 (UniProt - Evidence at protein level)

neXtProt

 NX_O95229

Antibodypedia

 ZWINT antibodies

PROTEIN BROWSER
ZWINT-002
ZWINT-006
ZWINT-009
ZWINT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZWINT-002
ENSP00000322850
ENST00000318387
A6NH27 [Direct mapping]
ZW10 interactor; cDNA FLJ36489 fis, clone THYMU2018126, highly similar to ZW10 interactor; cDNA FLJ60420, highly similar to ZW10 interactor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000776 [kinetochore]
GO:0007093 [mitotic cell cycle checkpoint]
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 157 aa
18.2 kDa 		No 0
ZWINT-006
ENSP00000354921
ENST00000361148
O95229 [Direct mapping]
ZW10 interactor
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000070 [mitotic sister chromatid segregation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0047485 [protein N-terminus binding]
GO:0051301 [cell division]
GO:0051649 [establishment of localization in cell]
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 230 aa
25.5 kDa 		No 0
ZWINT-009
ENSP00000363055
ENST00000373944
O95229 [Direct mapping]
ZW10 interactor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000070 [mitotic sister chromatid segregation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030425 [dendrite]
GO:0043005 [neuron projection]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0047485 [protein N-terminus binding]
GO:0051301 [cell division]
GO:0051649 [establishment of localization in cell]
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 277 aa
31.3 kDa 		No 0
ZWINT-201
ENSP00000378801
ENST00000395405
O95229 [Direct mapping]
ZW10 interactor
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0047485 [protein N-terminus binding]
GO:0051301 [cell division]
GO:0051649 [establishment of localization in cell]
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 277 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.