Cell atlas - ACADS - The Human Protein Atlas

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ACADS

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ACADS
Gene description	Acyl-CoA dehydrogenase, C-2 to C-3 short chain
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA004799
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

Mitochondria (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004799	Hep G2	Nucleoplasm
	HPA004799	Hep G2	Mitochondria

GENE INFORMATION
Gene name	ACADS (HGNC Symbol)
Synonyms	ACAD3, SCAD
Description	Acyl-CoA dehydrogenase, C-2 to C-3 short chain (HGNC Symbol)
Entrez gene summary	This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	120725735 - 120740008
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122971 (version 83.38)
Entrez gene	35
UniProt	P16219 (UniProt - Evidence at protein level)
neXtProt	NX_P16219
Antibodypedia	ACADS antibodies

PROTEIN BROWSER

ACADS-001	ACADS-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACADS-001 ENSP00000242592 ENST00000242592	P16219 [Direct mapping] Short-chain specific acyl-CoA dehydrogenase, mitochondrial E5KSD5 [Target identity:100%; Query identity:100%] Acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; Mitochondrial short-chain specific acyl-CoA dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0004085 [butyryl-CoA dehydrogenase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0042594 [response to starvation] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046359 [butyrate catabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0051289 [protein homotetramerization] GO:0051384 [response to glucocorticoid] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] Show all	412 aa 44.3 kDa	No	0
ACADS-002 ENSP00000401045 ENST00000411593	E9PE82 [Direct mapping] Short-chain-specific acyl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	408 aa 44 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.