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ACADS

GENERAL INFORMATION

Gene name

 ACADS

Gene description

 Acyl-CoA dehydrogenase, C-2 to C-3 short chain

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending retesting.

Reliability score

 Supported based on 3 antibodies.
HPA004799 , HPA022271 , CAB019284
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ACADS (HGNC Symbol)

Synonyms

 ACAD3, SCAD

Description

 Acyl-CoA dehydrogenase, C-2 to C-3 short chain (HGNC Symbol)

Entrez gene summary

 This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 120725735 - 120740008

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122971 (version 83.38)

Entrez gene

 35

UniProt

 P16219 (UniProt - Evidence at protein level)

neXtProt

 NX_P16219

Antibodypedia

 ACADS antibodies

PROTEIN BROWSER
ACADS-001
ACADS-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACADS-001
ENSP00000242592
ENST00000242592
P16219 [Direct mapping]
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
E5KSD5 [Target identity:100%; Query identity:100%]
Acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; Mitochondrial short-chain specific acyl-CoA dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0004085 [butyryl-CoA dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0042594 [response to starvation]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046359 [butyrate catabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051289 [protein homotetramerization]
GO:0051384 [response to glucocorticoid]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
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 412 aa
44.3 kDa 		No 0
ACADS-002
ENSP00000401045
ENST00000411593
E9PE82 [Direct mapping]
Short-chain-specific acyl-CoA dehydrogenase, mitochondrial
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 408 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.