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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDK2
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDK2

Gene description

Cyclin-dependent kinase 2

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in subsets of cells in the intestinal tract and squamous epithelia, cells in germinal centers and seminiferous ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB013115
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB013115

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant melanomas and cervical cancers displayed moderate to strong nuclear and cytoplasmic staining. Several malignant lymphomas, breast and ovarian cancers along with a few colorectal cancers were moderately stained. Remaining malignant cells were in general weakly stained or negative.

GENE INFORMATION

Gene name

CDK2

Synonyms

Description

Cyclin-dependent kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

12

Cytoband

q13.2

Chromosome location (bp)

55966769 - 55972784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123374 (version 83.38)

Entrez gene

1017

UniProt

P24941 (UniProt - Evidence at protein level)

neXtProt

NX_P24941

Antibodypedia

CDK2 antibodies

PROTEIN BROWSER

CDK2-001
CDK2-002
CDK2-003
CDK2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK2-001
ENSP00000266970
ENST00000266970
P24941 [Direct mapping]
Cyclin-dependent kinase 2
A0A024RB77 [Target identity:100%; Query identity:100%]
Cyclin-dependent kinase 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000793 [condensed chromosome]
GO:0000805 [X chromosome]
GO:0000806 [Y chromosome]
GO:0002088 [lens development in camera-type eye]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006813 [potassium ion transport]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007067 [mitotic nuclear division]
GO:0007126 [meiotic nuclear division]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009636 [response to toxic substance]
GO:0015030 [Cajal body]
GO:0016301 [kinase activity]
GO:0016572 [histone phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030332 [cyclin binding]
GO:0031100 [organ regeneration]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0032298 [positive regulation of DNA-dependent DNA replication initiation]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0035173 [histone kinase activity]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045471 [response to ethanol]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046686 [response to cadmium ion]
GO:0046872 [metal ion binding]
GO:0051298 [centrosome duplication]
GO:0051301 [cell division]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051591 [response to cAMP]
GO:0051602 [response to electrical stimulus]
GO:0051726 [regulation of cell cycle]
GO:0060968 [regulation of gene silencing]
GO:0071732 [cellular response to nitric oxide]
Show all
298 aa
33.9 kDa
No 0
CDK2-002
ENSP00000243067
ENST00000354056
P24941 [Direct mapping]
Cyclin-dependent kinase 2
A0A024RB10 [Target identity:100%; Query identity:100%]
Cyclin-dependent kinase 2, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006468 [protein phosphorylation]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007067 [mitotic nuclear division]
GO:0007126 [meiotic nuclear division]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0015030 [Cajal body]
GO:0016572 [histone phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030332 [cyclin binding]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035173 [histone kinase activity]
GO:0046872 [metal ion binding]
GO:0051298 [centrosome duplication]
GO:0051301 [cell division]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0060968 [regulation of gene silencing]
GO:0071732 [cellular response to nitric oxide]
Show all
264 aa
30 kDa
No 0
CDK2-003
ENSP00000393605
ENST00000440311
E7ESI2 [Direct mapping]
Cyclin-dependent kinase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
238 aa
27.2 kDa
No 0
CDK2-007
ENSP00000452514
ENST00000553376
G3V5T9 [Direct mapping]
Cyclin-dependent kinase 2; Cyclin-dependent kinase 2, isoform CRA_c
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
346 aa
39.2 kDa
No 0

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