We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
DBH
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DBH

Gene description

Dopamine beta-hydroxylase (dopamine beta-monooxygenase)

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (SH-SY5Y)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in adrenal medulla, peripheral nerves and liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA002130 , HPA070789
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA002130
HPA070789

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancers were essentially negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic positivity was observed in a few cases of liver cancer. All other cancers were essentially negative.

GENE INFORMATION

Gene name

DBH (HGNC Symbol)

Synonyms

DBM

Description

Dopamine beta-hydroxylase (dopamine beta-monooxygenase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

133636360 - 133659344

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123454 (version 83.38)

Entrez gene

1621

UniProt

P09172 (UniProt - Evidence at protein level)

neXtProt

NX_P09172

Antibodypedia

DBH antibodies

PROTEIN BROWSER

DBH-001
DBH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DBH-001
ENSP00000376776
ENST00000393056
P09172 [Direct mapping]
Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001816 [cytokine production]
GO:0001974 [blood vessel remodeling]
GO:0001975 [response to amphetamine]
GO:0002443 [leukocyte mediated immunity]
GO:0003824 [catalytic activity]
GO:0004497 [monooxygenase activity]
GO:0004500 [dopamine beta-monooxygenase activity]
GO:0005507 [copper ion binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0007268 [synaptic transmission]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016715 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen]
GO:0030658 [transport vesicle membrane]
GO:0031418 [L-ascorbic acid binding]
GO:0034466 [chromaffin granule lumen]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0034774 [secretory granule lumen]
GO:0042127 [regulation of cell proliferation]
GO:0042309 [homoiothermy]
GO:0042420 [dopamine catabolic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042584 [chromaffin granule membrane]
GO:0042593 [glucose homeostasis]
GO:0042596 [fear response]
GO:0042711 [maternal behavior]
GO:0044281 [small molecule metabolic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048149 [behavioral response to ethanol]
GO:0048265 [response to pain]
GO:0050900 [leukocyte migration]
GO:0055114 [oxidation-reduction process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
617 aa
69.1 kDa
No 0
DBH-002
ENSP00000263611
ENST00000263611
Q5T382 [Direct mapping]
Dopamine beta-hydroxylase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004497 [monooxygenase activity]
GO:0005507 [copper ion binding]
GO:0016715 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
244 aa
27.3 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.