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Gene name

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DBH
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

DBH

Gene description

Dopamine beta-hydroxylase (dopamine beta-monooxygenase)

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Group enriched (adrenal gland, liver)
FANTOM5:Group enriched (liver, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in adrenal medulla, peripheral nerves and liver.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA002130 , HPA070789
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, seminal vesicle)

GENE INFORMATION

Gene name

DBH (HGNC Symbol)

Synonyms

DBM

Description

Dopamine beta-hydroxylase (dopamine beta-monooxygenase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

133636360 - 133659344

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123454 (version 83.38)

Entrez gene

1621

UniProt

P09172 (UniProt - Evidence at protein level)

neXtProt

NX_P09172

Antibodypedia

DBH antibodies

PROTEIN BROWSER

DBH-001
DBH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DBH-001
ENSP00000376776
ENST00000393056
P09172 [Direct mapping]
Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001816 [cytokine production]
GO:0001974 [blood vessel remodeling]
GO:0001975 [response to amphetamine]
GO:0002443 [leukocyte mediated immunity]
GO:0003824 [catalytic activity]
GO:0004497 [monooxygenase activity]
GO:0004500 [dopamine beta-monooxygenase activity]
GO:0005507 [copper ion binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0007268 [synaptic transmission]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016715 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen]
GO:0030658 [transport vesicle membrane]
GO:0031418 [L-ascorbic acid binding]
GO:0034466 [chromaffin granule lumen]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0034774 [secretory granule lumen]
GO:0042127 [regulation of cell proliferation]
GO:0042309 [homoiothermy]
GO:0042420 [dopamine catabolic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042584 [chromaffin granule membrane]
GO:0042593 [glucose homeostasis]
GO:0042596 [fear response]
GO:0042711 [maternal behavior]
GO:0044281 [small molecule metabolic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048149 [behavioral response to ethanol]
GO:0048265 [response to pain]
GO:0050900 [leukocyte migration]
GO:0055114 [oxidation-reduction process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
617 aa
69.1 kDa
No 0
DBH-002
ENSP00000263611
ENST00000263611
Q5T382 [Direct mapping]
Dopamine beta-hydroxylase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004497 [monooxygenase activity]
GO:0005507 [copper ion binding]
GO:0016715 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
244 aa
27.3 kDa
Yes 0

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