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HJURP

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GENERAL INFORMATION

Gene name

 HJURP

Gene description

 Holliday junction recognition protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & nucleoli. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated), Nucleoli (validated)

Additional location

 In addition localized to the Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by custom assay

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA008436 , HPA027261
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & nucleoli. In addition localized to the cytosol.

Main location

 Nucleus (validated), Nucleoli (validated)

Additional location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA027261 RH-30 Nucleus Spatial
Nucleoli Spatial
HPA027261 U-2 OS Nucleus Spatial
Nucleoli Spatial
Mitochondria
HPA008436 A-431 Nucleus Spatial
Nucleoli Spatial
HPA008436 U-2 OS Nucleus Spatial
 Spatial
Nucleoli Spatial
 Spatial
Cytosol

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA008436 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. HJURP is mostly expressed during S and/or G2, and during Mitosis.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to custom assay

Spatial variation

 Nucleoli, Nucleus

GENE INFORMATION

Gene name

 HJURP (HGNC Symbol)

Synonyms

 DKFZp762E1312, FAKTS, hFLEG1, URLC9

Description

 Holliday junction recognition protein (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 233833416 - 233854566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123485 (version 83.38)

Entrez gene

 55355

UniProt

 Q8NCD3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCD3

Antibodypedia

 HJURP antibodies

PROTEIN BROWSER
HJURP-001
HJURP-002
HJURP-007
HJURP-201
HJURP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HJURP-001
ENSP00000414109
ENST00000411486
Q8NCD3 [Direct mapping]
Holliday junction recognition protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042393 [histone binding]
GO:0042802 [identical protein binding]
GO:0043254 [regulation of protein complex assembly]
GO:0051101 [regulation of DNA binding]
Show all
 748 aa
83.5 kDa 		No 0
HJURP-002
ENSP00000414051
ENST00000454020
H7C3V8 [Direct mapping]
Holliday junction recognition protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 268 aa
29.3 kDa 		No 0
HJURP-007
ENSP00000393253
ENST00000414924
C9JWC4 [Direct mapping]
Holliday junction recognition protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0042393 [histone binding]
Show all
 570 aa
64.3 kDa 		No 0
HJURP-201
ENSP00000407208
ENST00000432087
Q8NCD3 [Direct mapping]
Holliday junction recognition protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042393 [histone binding]
GO:0042802 [identical protein binding]
GO:0043254 [regulation of protein complex assembly]
GO:0051101 [regulation of DNA binding]
Show all
 694 aa
78 kDa 		No 0
HJURP-202
ENSP00000401944
ENST00000441687
Q8NCD3 [Direct mapping]
Holliday junction recognition protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042393 [histone binding]
GO:0042802 [identical protein binding]
GO:0043254 [regulation of protein complex assembly]
GO:0051101 [regulation of DNA binding]
Show all
 663 aa
74.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.