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HJURP

GENERAL INFORMATION

Gene name

 HJURP

Gene description

 Holliday junction recognition protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (bone marrow, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA008436
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable), lung cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008436

GENE INFORMATION

Gene name

 HJURP (HGNC Symbol)

Synonyms

 DKFZp762E1312, FAKTS, hFLEG1, URLC9

Description

 Holliday junction recognition protein (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 233833416 - 233854566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123485 (version 83.38)

Entrez gene

 55355

UniProt

 Q8NCD3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCD3

Antibodypedia

 HJURP antibodies

PROTEIN BROWSER
HJURP-001
HJURP-002
HJURP-007
HJURP-201
HJURP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HJURP-001
ENSP00000414109
ENST00000411486
Q8NCD3 [Direct mapping]
Holliday junction recognition protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042393 [histone binding]
GO:0042802 [identical protein binding]
GO:0043254 [regulation of protein complex assembly]
GO:0051101 [regulation of DNA binding]
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 748 aa
83.5 kDa 		No 0
HJURP-002
ENSP00000414051
ENST00000454020
H7C3V8 [Direct mapping]
Holliday junction recognition protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 268 aa
29.3 kDa 		No 0
HJURP-007
ENSP00000393253
ENST00000414924
C9JWC4 [Direct mapping]
Holliday junction recognition protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0042393 [histone binding]
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 570 aa
64.3 kDa 		No 0
HJURP-201
ENSP00000407208
ENST00000432087
Q8NCD3 [Direct mapping]
Holliday junction recognition protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042393 [histone binding]
GO:0042802 [identical protein binding]
GO:0043254 [regulation of protein complex assembly]
GO:0051101 [regulation of DNA binding]
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 694 aa
78 kDa 		No 0
HJURP-202
ENSP00000401944
ENST00000441687
Q8NCD3 [Direct mapping]
Holliday junction recognition protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042393 [histone binding]
GO:0042802 [identical protein binding]
GO:0043254 [regulation of protein complex assembly]
GO:0051101 [regulation of DNA binding]
Show all
 663 aa
74.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.