Cell atlas - IL13RA2 - The Human Protein Atlas

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IL13RA2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IL13RA2
Gene description	Interleukin 13 receptor, alpha 2
Protein class	Cancer-related genes CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus.
RNA cell category	Group enriched (U-2197, U-251 MG, U-87 MG, PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055552
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-2197, U-251 MG, U-87 MG, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055552	PC-3	Nucleus
	HPA055552	PC-3	Nucleoli
	HPA055552	U-2 OS	Nucleus
	HPA055552	U-2 OS	Nucleoli	Intensity
	HPA055552	U-251 MG	Nucleus
	HPA055552	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	IL13RA2 (HGNC Symbol)
Synonyms	CD213a2, CT19, IL-13R, IL13BP
Description	Interleukin 13 receptor, alpha 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	115003975 - 115019977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123496 (version 83.38)
Entrez gene	3598
UniProt	Q14627 (UniProt - Evidence at protein level)
neXtProt	NX_Q14627
Antibodypedia	IL13RA2 antibodies

PROTEIN BROWSER

IL13RA2-001	IL13RA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL13RA2-001 ENSP00000361004 ENST00000371936	Q14627 [Direct mapping] Interleukin-13 receptor subunit alpha-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002638 [negative regulation of immunoglobulin production] GO:0004871 [signal transducer activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016064 [immunoglobulin mediated immune response] GO:0019221 [cytokine-mediated signaling pathway] GO:0043305 [negative regulation of mast cell degranulation] GO:0071260 [cellular response to mechanical stimulus] Show all	380 aa 44.2 kDa	Yes	1
IL13RA2-201 ENSP00000243213 ENST00000243213	Q14627 [Direct mapping] Interleukin-13 receptor subunit alpha-2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	380 aa 44.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.