Cell atlas - NRK - The Human Protein Atlas

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NRK

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NRK
Gene description	Nik related kinase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Group enriched (RPTEC TERT1, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017238
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017238	RH-30	Nucleoplasm
	HPA017238	RH-30	Cytosol
	HPA017238	U-251 MG	Nucleoplasm
	HPA017238	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NRK (HGNC Symbol)
Synonyms	DKFZp686A17109
Description	Nik related kinase (HGNC Symbol)
Entrez gene summary	The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	105822543 - 105958610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123572 (version 83.38)
Entrez gene	203447
UniProt	Q7Z2Y5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z2Y5
Antibodypedia	NRK antibodies

PROTEIN BROWSER

NRK-001	NRK-002	NRK-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRK-001 ENSP00000434830 ENST00000243300	Q7Z2Y5 [Direct mapping] Nik-related protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007256 [activation of JNKK activity] GO:0007346 [regulation of mitotic cell cycle] GO:0007567 [parturition] GO:0008285 [negative regulation of cell proliferation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031532 [actin cytoskeleton reorganization] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0048812 [neuron projection morphogenesis] GO:0060721 [regulation of spongiotrophoblast cell proliferation] Show all	1582 aa 178.5 kDa	No	0
NRK-002 ENSP00000438148 ENST00000540278	B7Z1I7 [Direct mapping] Nik-related protein kinase; cDNA FLJ50079, highly similar to Homo sapiens Nik related kinase (NRK), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0005737 [cytoplasm] GO:0007346 [regulation of mitotic cell cycle] GO:0016021 [integral component of membrane] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031532 [actin cytoskeleton reorganization] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0048812 [neuron projection morphogenesis] Show all	163 aa 18.8 kDa	No	1
NRK-005 ENSP00000438785 ENST00000536164	Q7Z2Y5 [Direct mapping] Nik-related protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031532 [actin cytoskeleton reorganization] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0048812 [neuron projection morphogenesis] Show all	188 aa 21.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.