Expression of NRK in cancer - Summary - The Human Protein Atlas

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NRK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NRK
Gene description	Nik related kinase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Group enriched (RH-30, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (ovary, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA017238
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017238

GENE INFORMATION
Gene name	NRK (HGNC Symbol)
Synonyms	DKFZp686A17109
Description	Nik related kinase (HGNC Symbol)
Entrez gene summary	The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	105822543 - 105958610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123572 (version 83.38)
Entrez gene	203447
UniProt	Q7Z2Y5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z2Y5
Antibodypedia	NRK antibodies

PROTEIN BROWSER

NRK-001	NRK-002	NRK-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRK-001 ENSP00000434830 ENST00000243300	Q7Z2Y5 [Direct mapping] Nik-related protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007256 [activation of JNKK activity] GO:0007346 [regulation of mitotic cell cycle] GO:0007567 [parturition] GO:0008285 [negative regulation of cell proliferation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031532 [actin cytoskeleton reorganization] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0048812 [neuron projection morphogenesis] GO:0060721 [regulation of spongiotrophoblast cell proliferation] Show all	1582 aa 178.5 kDa	No	0
NRK-002 ENSP00000438148 ENST00000540278	B7Z1I7 [Direct mapping] Nik-related protein kinase; cDNA FLJ50079, highly similar to Homo sapiens Nik related kinase (NRK), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0005737 [cytoplasm] GO:0007346 [regulation of mitotic cell cycle] GO:0016021 [integral component of membrane] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031532 [actin cytoskeleton reorganization] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0048812 [neuron projection morphogenesis] Show all	163 aa 18.8 kDa	No	1
NRK-005 ENSP00000438785 ENST00000536164	Q7Z2Y5 [Direct mapping] Nik-related protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031532 [actin cytoskeleton reorganization] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0048812 [neuron projection morphogenesis] Show all	188 aa 21.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.