Expression of DNPEP in cancer - Summary - The Human Protein Atlas

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DNPEP

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNPEP
Gene description	Aspartyl aminopeptidase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression of varying intensity.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036398 , HPA044860
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036398	HPA044860

GENE INFORMATION
Gene name	DNPEP (HGNC Symbol)
Synonyms	ASPEP, DAP
Description	Aspartyl aminopeptidase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219373546 - 219400022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123992 (version 83.38)
Entrez gene	23549
UniProt	Q9ULA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULA0
Antibodypedia	DNPEP antibodies

PROTEIN BROWSER

DNPEP-001	DNPEP-005	DNPEP-006	DNPEP-007	DNPEP-008	DNPEP-013	DNPEP-014	DNPEP-015	DNPEP-017	DNPEP-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNPEP-001 ENSP00000273075 ENST00000273075	Q9ULA0 [Direct mapping] Aspartyl aminopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0072562 [blood microparticle] Show all	485 aa 53.4 kDa	No	0
DNPEP-005 ENSP00000363083 ENST00000373972	E7EMB6 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	410 aa 45 kDa	No	0
DNPEP-006 ENSP00000400944 ENST00000429013	F8WAN0 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	273 aa 30.3 kDa	No	0
DNPEP-007 ENSP00000414739 ENST00000430206	C9JRG3 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	117 aa 13 kDa	No	0
DNPEP-008 ENSP00000317252 ENST00000322176	B9ZVU2 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	270 aa 29.9 kDa	No	0
DNPEP-013 ENSP00000410684 ENST00000457935	C9JBE1 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	331 aa 36.6 kDa	No	0
DNPEP-014 ENSP00000412003 ENST00000434339	C9J1E2 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	138 aa 15.3 kDa	No	0
DNPEP-015 ENSP00000431076 ENST00000523282	E7ETB3 [Direct mapping] Aspartyl aminopeptidase; Aspartyl aminopeptidase, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	493 aa 54.5 kDa	No	0
DNPEP-017 ENSP00000430630 ENST00000519905	E5RJ35 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	89 aa 9.8 kDa	No	0
DNPEP-019 ENSP00000429960 ENST00000521459	E7EPX3 [Direct mapping] Aspartyl aminopeptidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	224 aa 24.9 kDa	No	1

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