Expression of PI3 in cancer - Summary - The Human Protein Atlas

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PI3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PI3
Gene description	Peptidase inhibitor 3, skin-derived
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Group enriched (EFO-21, HaCaT, PC-3)
HPA (normal tissue):	Group enriched (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA017737 , CAB009449
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (unfavourable), pancreatic cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Pancreatic cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Cervical cancer

STAINING SUMMARY

HPA017737	CAB009449

GENE INFORMATION
Gene name	PI3 (HGNC Symbol)
Synonyms	cementoin, ELAFIN, ESI, SKALP, WAP3, WFDC14
Description	Peptidase inhibitor 3, skin-derived (HGNC Symbol)
Entrez gene summary	This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45174876 - 45176544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124102 (version 83.38)
Entrez gene	5266
UniProt	P19957 (UniProt - Evidence at protein level)
neXtProt	NX_P19957
Antibodypedia	PI3 antibodies

PROTEIN BROWSER

PI3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PI3-001 ENSP00000243924 ENST00000243924	P19957 [Direct mapping] Elafin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0007620 [copulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	117 aa 12.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.