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RNA tissue category: Group enriched (esophagus, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, salivary gland, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)
GENE INFORMATION
Gene name
PI3 (HGNC Symbol)
Synonyms
cementoin, ELAFIN, ESI, SKALP, WAP3, WFDC14
Description
Peptidase inhibitor 3, skin-derived (HGNC Symbol)
Entrez gene summary
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
