Expression of ARHGAP40 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ARHGAP40

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGAP40
Gene description	Rho GTPase activating protein 40
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, RPTEC TERT1, SK-BR-3, T-47d)
HPA (normal tissue):	Group enriched (breast, epididymis, esophagus, seminal vesicle, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA data suggests high expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA042636 , HPA042840
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042636	HPA042840

GENE INFORMATION
Gene name	ARHGAP40 (HGNC Symbol)
Synonyms	C20orf95, dJ1100H13.4
Description	Rho GTPase activating protein 40 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	38601934 - 38651035
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124143 (version 83.38)
Entrez gene	343578
UniProt	Q5TG30 (UniProt - Inferred from homology)
neXtProt	NX_Q5TG30
Antibodypedia	ARHGAP40 antibodies

PROTEIN BROWSER

ARHGAP40-001	ARHGAP40-003	ARHGAP40-004	ARHGAP40-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP40-001 ENSP00000243967 ENST00000243967	H7BXE0 [Direct mapping] Rho GTPase-activating protein 40 Show all	Predicted intracellular proteins Show all	GO:0007165 [signal transduction] Show all	592 aa 65 kDa	No	0
ARHGAP40-003 ENSP00000362443 ENST00000373346	H0Y397 [Direct mapping] Rho GTPase-activating protein 40 Show all	Predicted intracellular proteins Show all		154 aa 17.2 kDa	No	0
ARHGAP40-004 ENSP00000414822 ENST00000414158	H0Y7S1 [Direct mapping] Rho GTPase-activating protein 40 Show all	Predicted intracellular proteins Show all		72 aa 7.8 kDa	No	0
ARHGAP40-201 ENSP00000362442 ENST00000373345	Q5TG30 [Direct mapping] Rho GTPase-activating protein 40 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	622 aa 68.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.