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TOX2

GENERAL INFORMATION

Gene name

 TOX2

Gene description

 TOX high mobility group box family member 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a subset of immune cells in lymphoid germinal center cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA049900
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TOX2 (HGNC Symbol)

Synonyms

 C20orf100, dJ1108D11.2, GCX-1

Description

 TOX high mobility group box family member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 43914864 - 44069616

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124191 (version 83.38)

Entrez gene

 84969

UniProt

 Q96NM4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96NM4

Antibodypedia

 TOX2 antibodies

PROTEIN BROWSER
TOX2-001
TOX2-002
TOX2-003
TOX2-004
TOX2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOX2-001
ENSP00000350849
ENST00000358131
Q96NM4 [Direct mapping]
TOX high mobility group box family member 2
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 488 aa
51.6 kDa 		No 0
TOX2-002
ENSP00000362090
ENST00000372999
Q96NM4 [Direct mapping]
TOX high mobility group box family member 2
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 464 aa
49.1 kDa 		No 0
TOX2-003
ENSP00000344724
ENST00000341197
Q96NM4 [Direct mapping]
TOX high mobility group box family member 2
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008585 [female gonad development]
GO:0034698 [response to gonadotropin]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 506 aa
53.4 kDa 		No 0
TOX2-004
ENSP00000390876
ENST00000413823
Q5JYD4 [Direct mapping]
TOX high mobility group box family member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 196 aa
20.7 kDa 		No 0
TOX2-006
ENSP00000390278
ENST00000423191
Q96NM4 [Direct mapping]
TOX high mobility group box family member 2
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 464 aa
49.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.