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MPHOSPH10

GENERAL INFORMATION

Gene name

 MPHOSPH10

Gene description

 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolar expression, most abundant in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA035059 , HPA035060
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035059
HPA035060

GENE INFORMATION

Gene name

 MPHOSPH10 (HGNC Symbol)

Synonyms

 CT90, MPP10, MPP10P, PPP1R106

Description

 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 71130314 - 71150101

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124383 (version 83.38)

Entrez gene

 10199

UniProt

 O00566 (UniProt - Evidence at protein level)

neXtProt

 NX_O00566

Antibodypedia

 MPHOSPH10 antibodies

PROTEIN BROWSER
MPHOSPH10-001
MPHOSPH10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MPHOSPH10-001
ENSP00000244230
ENST00000244230
O00566 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein MPP10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000375 [RNA splicing, via transesterification reactions]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0006364 [rRNA processing]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0010923 [negative regulation of phosphatase activity]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
GO:0044822 [poly(A) RNA binding]
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 681 aa
78.9 kDa 		No 0
MPHOSPH10-002
ENSP00000475545
ENST00000498451
U3KQ48 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein MPP10
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0006364 [rRNA processing]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
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 462 aa
53.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.