Expression of BTN1A1 in cancer - Summary - The Human Protein Atlas

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BTN1A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BTN1A1
Gene description	Butyrophilin, subfamily 1, member A1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (breast cancer)
HPA (cell line):	Cell line enriched (CACO-2)
HPA (normal tissue):	Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in glandular cells of lactating breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA011126
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011126

GENE INFORMATION
Gene name	BTN1A1 (HGNC Symbol)
Synonyms	BT, BTN, BTN1
Description	Butyrophilin, subfamily 1, member A1 (HGNC Symbol)
Entrez gene summary	Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26501221 - 26510422
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124557 (version 83.38)
Entrez gene	696
UniProt	Q13410 (UniProt - Evidence at protein level)
neXtProt	NX_Q13410
Antibodypedia	BTN1A1 antibodies

PROTEIN BROWSER

BTN1A1-001	BTN1A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTN1A1-001 ENSP00000244513 ENST00000244513	Q13410 [Direct mapping] Butyrophilin subfamily 1 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] Show all	526 aa 59 kDa	Yes	1
BTN1A1-201 ENSP00000484707 ENST00000613186	Q4VAN1 [Direct mapping] BTN1A1 protein; Butyrophilin subfamily 1 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	494 aa 55.5 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.