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BTN1A1

GENERAL INFORMATION

Gene name

 BTN1A1

Gene description

 Butyrophilin, subfamily 1, member A1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (breast)
GTEx:Tissue enhanced (breast)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in glandular cells of lactating breast.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA011126
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Lactating breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (breast)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (breast)

GENE INFORMATION

Gene name

 BTN1A1 (HGNC Symbol)

Synonyms

 BT, BTN, BTN1

Description

 Butyrophilin, subfamily 1, member A1 (HGNC Symbol)

Entrez gene summary

 Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 26501221 - 26510422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124557 (version 83.38)

Entrez gene

 696

UniProt

 Q13410 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13410

Antibodypedia

 BTN1A1 antibodies

PROTEIN BROWSER
BTN1A1-001
BTN1A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BTN1A1-001
ENSP00000244513
ENST00000244513
Q13410 [Direct mapping]
Butyrophilin subfamily 1 member A1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
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 526 aa
59 kDa 		Yes 1
BTN1A1-201
ENSP00000484707
ENST00000613186
Q4VAN1 [Direct mapping]
BTN1A1 protein; Butyrophilin subfamily 1 member A1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
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 494 aa
55.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.