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SLC17A3

GENERAL INFORMATION

Gene name

 SLC17A3

Gene description

 Solute carrier family 17 (organic anion transporter), member 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Cell line enriched (RPTEC TERT1)
HPA (normal tissue):Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous staining in kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending reevaluation.

Reliability score

 Uncertain based on 1 antibody.
HPA016569
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA016569

GENE INFORMATION

Gene name

 SLC17A3 (HGNC Symbol)

Synonyms

 NPT4

Description

 Solute carrier family 17 (organic anion transporter), member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 25833066 - 25882286

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124564 (version 83.38)

Entrez gene

 10786

UniProt

 O00476 (UniProt - Evidence at protein level)

neXtProt

 NX_O00476

Antibodypedia

 SLC17A3 antibodies

PROTEIN BROWSER
SLC17A3-001
SLC17A3-002
SLC17A3-003
SLC17A3-004
SLC17A3-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC17A3-001
ENSP00000353873
ENST00000360657
O00476 [Direct mapping]
Sodium-dependent phosphate transport protein 4
A0A024QZX7 [Target identity:100%; Query identity:100%]
Solute carrier family 17 (Sodium phosphate), member 3, isoform CRA_a
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Show all
GO:0005436 [sodium:phosphate symporter activity]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0006855 [drug transmembrane transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015143 [urate transmembrane transporter activity]
GO:0015238 [drug transmembrane transporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015747 [urate transport]
GO:0015760 [glucose-6-phosphate transport]
GO:0015893 [drug transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019534 [toxin transporter activity]
GO:0031526 [brush border membrane]
GO:0034220 [ion transmembrane transport]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
GO:0046415 [urate metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055085 [transmembrane transport]
GO:1901998 [toxin transport]
GO:1903825 [organic acid transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 420 aa
46.1 kDa 		No 9
SLC17A3-002
ENSP00000380250
ENST00000397060
O00476 [Direct mapping]
Sodium-dependent phosphate transport protein 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005436 [sodium:phosphate symporter activity]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0006855 [drug transmembrane transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015143 [urate transmembrane transporter activity]
GO:0015238 [drug transmembrane transporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015747 [urate transport]
GO:0015760 [glucose-6-phosphate transport]
GO:0015893 [drug transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019534 [toxin transporter activity]
GO:0031526 [brush border membrane]
GO:0034220 [ion transmembrane transport]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
GO:0046415 [urate metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055085 [transmembrane transport]
GO:1901998 [toxin transport]
GO:1903825 [organic acid transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 498 aa
54.3 kDa 		No >9
SLC17A3-003
ENSP00000355307
ENST00000361703
O00476 [Direct mapping]
Sodium-dependent phosphate transport protein 4
A0A024QZX7 [Target identity:100%; Query identity:100%]
Solute carrier family 17 (Sodium phosphate), member 3, isoform CRA_a
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005436 [sodium:phosphate symporter activity]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0006855 [drug transmembrane transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0008514 [organic anion transmembrane transporter activity]
GO:0015143 [urate transmembrane transporter activity]
GO:0015238 [drug transmembrane transporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015747 [urate transport]
GO:0015760 [glucose-6-phosphate transport]
GO:0015893 [drug transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019534 [toxin transporter activity]
GO:0031526 [brush border membrane]
GO:0034220 [ion transmembrane transport]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
GO:0046415 [urate metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055085 [transmembrane transport]
GO:1901998 [toxin transport]
GO:1903825 [organic acid transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 420 aa
46.1 kDa 		No 9
SLC17A3-004
ENSP00000421855
ENST00000481949
H0Y8R7 [Direct mapping]
Sodium-dependent phosphate transport protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005436 [sodium:phosphate symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
GO:0055085 [transmembrane transport]
Show all
 99 aa
10.9 kDa 		No 2
SLC17A3-009
ENSP00000424027
ENST00000505420
H0Y9F7 [Direct mapping]
Sodium-dependent phosphate transport protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005436 [sodium:phosphate symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
Show all
 51 aa
6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.