Tissue expression of SLC17A3 - Summary - The Human Protein Atlas

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SLC17A3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC17A3
Gene description	Solute carrier family 17 (organic anion transporter), member 3
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (kidney)
GTEx:	Group enriched (kidney, liver)
FANTOM5:	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression

Membranous staining in kidney.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending reevaluation.
Reliability score	Uncertain based on 1 antibody. HPA016569
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION
Gene name	SLC17A3 (HGNC Symbol)
Synonyms	NPT4
Description	Solute carrier family 17 (organic anion transporter), member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	25833066 - 25882286
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124564 (version 83.38)
Entrez gene	10786
UniProt	O00476 (UniProt - Evidence at protein level)
neXtProt	NX_O00476
Antibodypedia	SLC17A3 antibodies

PROTEIN BROWSER

SLC17A3-001	SLC17A3-002	SLC17A3-003	SLC17A3-004	SLC17A3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC17A3-001 ENSP00000353873 ENST00000360657	O00476 [Direct mapping] Sodium-dependent phosphate transport protein 4 A0A024QZX7 [Target identity:100%; Query identity:100%] Solute carrier family 17 (Sodium phosphate), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0006817 [phosphate ion transport] GO:0006855 [drug transmembrane transport] GO:0008308 [voltage-gated anion channel activity] GO:0008514 [organic anion transmembrane transporter activity] GO:0015143 [urate transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0015562 [efflux transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015747 [urate transport] GO:0015760 [glucose-6-phosphate transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019534 [toxin transporter activity] GO:0031526 [brush border membrane] GO:0034220 [ion transmembrane transport] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0044341 [sodium-dependent phosphate transport] GO:0046415 [urate metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:1901998 [toxin transport] GO:1903825 [organic acid transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	420 aa 46.1 kDa	No	9
SLC17A3-002 ENSP00000380250 ENST00000397060	O00476 [Direct mapping] Sodium-dependent phosphate transport protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0006817 [phosphate ion transport] GO:0006855 [drug transmembrane transport] GO:0008308 [voltage-gated anion channel activity] GO:0008514 [organic anion transmembrane transporter activity] GO:0015143 [urate transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0015562 [efflux transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015747 [urate transport] GO:0015760 [glucose-6-phosphate transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019534 [toxin transporter activity] GO:0031526 [brush border membrane] GO:0034220 [ion transmembrane transport] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0044341 [sodium-dependent phosphate transport] GO:0046415 [urate metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:1901998 [toxin transport] GO:1903825 [organic acid transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	498 aa 54.3 kDa	No	>9
SLC17A3-003 ENSP00000355307 ENST00000361703	O00476 [Direct mapping] Sodium-dependent phosphate transport protein 4 A0A024QZX7 [Target identity:100%; Query identity:100%] Solute carrier family 17 (Sodium phosphate), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0006817 [phosphate ion transport] GO:0006855 [drug transmembrane transport] GO:0008308 [voltage-gated anion channel activity] GO:0008514 [organic anion transmembrane transporter activity] GO:0015143 [urate transmembrane transporter activity] GO:0015238 [drug transmembrane transporter activity] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0015562 [efflux transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015747 [urate transport] GO:0015760 [glucose-6-phosphate transport] GO:0015893 [drug transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019534 [toxin transporter activity] GO:0031526 [brush border membrane] GO:0034220 [ion transmembrane transport] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0044341 [sodium-dependent phosphate transport] GO:0046415 [urate metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:1901998 [toxin transport] GO:1903825 [organic acid transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	420 aa 46.1 kDa	No	9
SLC17A3-004 ENSP00000421855 ENST00000481949	H0Y8R7 [Direct mapping] Sodium-dependent phosphate transport protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0044341 [sodium-dependent phosphate transport] GO:0055085 [transmembrane transport] Show all	99 aa 10.9 kDa	No	2
SLC17A3-009 ENSP00000424027 ENST00000505420	H0Y9F7 [Direct mapping] Sodium-dependent phosphate transport protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005436 [sodium:phosphate symporter activity] GO:0015321 [sodium-dependent phosphate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0044341 [sodium-dependent phosphate transport] Show all	51 aa 6 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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