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SPDEF

GENERAL INFORMATION

Gene name

 SPDEF

Gene description

 SAM pointed domain containing ETS transcription factor

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, endometrial cancer, prostate cancer)
HPA (cell line):Cell line enhanced (MCF7, SK-BR-3, T-47d)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, endometrial cancer, prostate cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SPDEF (HGNC Symbol)

Synonyms

 bA375E1.3, PDEF

Description

 SAM pointed domain containing ETS transcription factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 34537802 - 34556333

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124664 (version 83.38)

Entrez gene

 25803

UniProt

 O95238 (UniProt - Evidence at protein level)

neXtProt

 NX_O95238

Antibodypedia

 SPDEF antibodies

PROTEIN BROWSER
SPDEF-001
SPDEF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPDEF-001
ENSP00000363149
ENST00000374037
O95238 [Direct mapping]
SAM pointed domain-containing Ets transcription factor
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0010454 [negative regulation of cell fate commitment]
GO:0010455 [positive regulation of cell fate commitment]
GO:0030154 [cell differentiation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060480 [lung goblet cell differentiation]
GO:0060576 [intestinal epithelial cell development]
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 335 aa
37.5 kDa 		No 0
SPDEF-201
ENSP00000442715
ENST00000544425
O95238 [Direct mapping]
SAM pointed domain-containing Ets transcription factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0030154 [cell differentiation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
Show all
 319 aa
35.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.