Tissue expression of SPDEF - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SPDEF
Gene description	SAM pointed domain containing ETS transcription factor
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (prostate)
GTEx:	Tissue enhanced (prostate, salivary gland)
FANTOM5:	Tissue enhanced (prostate, salivary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate, salivary gland)

GENE INFORMATION
Gene name	SPDEF (HGNC Symbol)
Synonyms	bA375E1.3, PDEF
Description	SAM pointed domain containing ETS transcription factor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	34537802 - 34556333
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124664 (version 83.38)
Entrez gene	25803
UniProt	O95238 (UniProt - Evidence at protein level)
neXtProt	NX_O95238
Antibodypedia	SPDEF antibodies

PROTEIN BROWSER

SPDEF-001	SPDEF-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPDEF-001 ENSP00000363149 ENST00000374037	O95238 [Direct mapping] SAM pointed domain-containing Ets transcription factor Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0010454 [negative regulation of cell fate commitment] GO:0010455 [positive regulation of cell fate commitment] GO:0030154 [cell differentiation] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060480 [lung goblet cell differentiation] GO:0060576 [intestinal epithelial cell development] Show all	335 aa 37.5 kDa	No	0
SPDEF-201 ENSP00000442715 ENST00000544425	O95238 [Direct mapping] SAM pointed domain-containing Ets transcription factor Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] Show all	319 aa 35.7 kDa	No	0