Expression of DNAH8 in cancer - Summary - The Human Protein Atlas

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DNAH8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNAH8
Gene description	Dynein, axonemal, heavy chain 8
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028447
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028447

GENE INFORMATION
Gene name	DNAH8 (HGNC Symbol)
Synonyms	hdhc9
Description	Dynein, axonemal, heavy chain 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	38715341 - 39030529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124721 (version 83.38)
Entrez gene	1769
UniProt	Q96JB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JB1
Antibodypedia	DNAH8 antibodies

PROTEIN BROWSER

DNAH8-001	DNAH8-002	DNAH8-003	DNAH8-004	DNAH8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAH8-001 ENSP00000352312 ENST00000359357	Q96JB1 [Direct mapping] Dynein heavy chain 8, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0001539 [cilium or flagellum-dependent cell motility] GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005858 [axonemal dynein complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] Show all	4490 aa 514.7 kDa	No	0
DNAH8-002 ENSP00000333363 ENST00000327475	A0A075B6F3 [Direct mapping] Dynein heavy chain 8, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] GO:0097228 [sperm principal piece] Show all	4707 aa 538.6 kDa	No	0
DNAH8-003 ENSP00000415331 ENST00000449981	H0Y7V4 [Direct mapping] Dynein heavy chain 8, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] Show all	4188 aa 478.9 kDa	No	0
DNAH8-004 ENSP00000377916 ENST00000394393	H3BLZ4 [Direct mapping] Dynein heavy chain 8, axonemal Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] Show all	135 aa 15.4 kDa	No	0
DNAH8-005 ENSP00000362375 ENST00000373278	Q8IU65 [Direct mapping] Axonemal dynein heavy chain 8 isoform 2; Axonemal dynein heavy chain 8 isoform 3; Dynein heavy chain 8, axonemal Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] Show all	217 aa 23.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.