Tissue expression of DNAH8 - Summary - The Human Protein Atlas

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DNAH8

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DNAH8
Gene description	Dynein, axonemal, heavy chain 8
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028447
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	DNAH8 (HGNC Symbol)
Synonyms	hdhc9
Description	Dynein, axonemal, heavy chain 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	38715341 - 39030529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124721 (version 83.38)
Entrez gene	1769
UniProt	Q96JB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JB1
Antibodypedia	DNAH8 antibodies

PROTEIN BROWSER

DNAH8-001	DNAH8-002	DNAH8-003	DNAH8-004	DNAH8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAH8-001 ENSP00000352312 ENST00000359357	Q96JB1 [Direct mapping] Dynein heavy chain 8, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0001539 [cilium or flagellum-dependent cell motility] GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005858 [axonemal dynein complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] Show all	4490 aa 514.7 kDa	No	0
DNAH8-002 ENSP00000333363 ENST00000327475	A0A075B6F3 [Direct mapping] Dynein heavy chain 8, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] GO:0097228 [sperm principal piece] Show all	4707 aa 538.6 kDa	No	0
DNAH8-003 ENSP00000415331 ENST00000449981	H0Y7V4 [Direct mapping] Dynein heavy chain 8, axonemal Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] GO:0030286 [dynein complex] Show all	4188 aa 478.9 kDa	No	0
DNAH8-004 ENSP00000377916 ENST00000394393	H3BLZ4 [Direct mapping] Dynein heavy chain 8, axonemal Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] Show all	135 aa 15.4 kDa	No	0
DNAH8-005 ENSP00000362375 ENST00000373278	Q8IU65 [Direct mapping] Axonemal dynein heavy chain 8 isoform 2; Axonemal dynein heavy chain 8 isoform 3; Dynein heavy chain 8, axonemal Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] Show all	217 aa 23.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.