Cell atlas - TREM1 - The Human Protein Atlas

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TREM1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TREM1
Gene description	Triggering receptor expressed on myeloid cells 1
Protein class	CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (U-87 MG)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TREM1 (HGNC Symbol)
Synonyms	CD354, TREM-1
Description	Triggering receptor expressed on myeloid cells 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41267926 - 41286719
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124731 (version 83.38)
Entrez gene	54210
UniProt	Q9NP99 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP99
Antibodypedia	TREM1 antibodies

PROTEIN BROWSER

TREM1-001	TREM1-002	TREM1-003	TREM1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TREM1-001 ENSP00000244709 ENST00000244709	Q9NP99 [Direct mapping] Triggering receptor expressed on myeloid cells 1 Q38L15 [Target identity:100%; Query identity:100%] Triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on myeloid cells 1, isoform CRA_a; cDNA, FLJ93589, Homo sapiens triggering receptor expressed on myeloid cells 1 (TREM1), mRNA Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0002374 [cytokine secretion involved in immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0005623 [cell] GO:0005886 [plasma membrane] GO:0006959 [humoral immune response] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030593 [neutrophil chemotaxis] GO:0035556 [intracellular signal transduction] GO:0042107 [cytokine metabolic process] GO:0045087 [innate immune response] GO:0050755 [chemokine metabolic process] GO:0050776 [regulation of immune response] GO:0050900 [leukocyte migration] GO:0070945 [neutrophil mediated killing of gram-negative bacterium] GO:0072672 [neutrophil extravasation] GO:0097110 [scaffold protein binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	234 aa 26.4 kDa	Yes	1
TREM1-002 ENSP00000334284 ENST00000334475	Q9NP99 [Direct mapping] Triggering receptor expressed on myeloid cells 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006959 [humoral immune response] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0050900 [leukocyte migration] GO:0097110 [scaffold protein binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	150 aa 17.6 kDa	Yes	0
TREM1-003 ENSP00000465345 ENST00000591620	Q9NP99 [Direct mapping] Triggering receptor expressed on myeloid cells 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006959 [humoral immune response] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0050900 [leukocyte migration] GO:0097110 [scaffold protein binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	225 aa 25.6 kDa	Yes	0
TREM1-007 ENSP00000465688 ENST00000589614	K7EKM5 [Direct mapping] Triggering receptor expressed on myeloid cells 1, isoform CRA_b; Triggering receptor-expressed on myeloid cells 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	250 aa 28.4 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.