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TREM1

GENERAL INFORMATION

Gene name

 TREM1

Gene description

 Triggering receptor expressed on myeloid cells 1

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, bone marrow, lung)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (lung, placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA005563
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, bone marrow, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, placenta)

GENE INFORMATION

Gene name

 TREM1 (HGNC Symbol)

Synonyms

 CD354, TREM-1

Description

 Triggering receptor expressed on myeloid cells 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 41267926 - 41286719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124731 (version 83.38)

Entrez gene

 54210

UniProt

 Q9NP99 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP99

Antibodypedia

 TREM1 antibodies

PROTEIN BROWSER
TREM1-001
TREM1-002
TREM1-003
TREM1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TREM1-001
ENSP00000244709
ENST00000244709
Q9NP99 [Direct mapping]
Triggering receptor expressed on myeloid cells 1
Q38L15 [Target identity:100%; Query identity:100%]
Triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on myeloid cells 1, isoform CRA_a; cDNA, FLJ93589, Homo sapiens triggering receptor expressed on myeloid cells 1 (TREM1), mRNA
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002374 [cytokine secretion involved in immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0005886 [plasma membrane]
GO:0006959 [humoral immune response]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0035556 [intracellular signal transduction]
GO:0042107 [cytokine metabolic process]
GO:0045087 [innate immune response]
GO:0050755 [chemokine metabolic process]
GO:0050776 [regulation of immune response]
GO:0050900 [leukocyte migration]
GO:0070945 [neutrophil mediated killing of gram-negative bacterium]
GO:0072672 [neutrophil extravasation]
GO:0097110 [scaffold protein binding]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 234 aa
26.4 kDa 		Yes 1
TREM1-002
ENSP00000334284
ENST00000334475
Q9NP99 [Direct mapping]
Triggering receptor expressed on myeloid cells 1
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CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006959 [humoral immune response]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
GO:0045087 [innate immune response]
GO:0050776 [regulation of immune response]
GO:0050900 [leukocyte migration]
GO:0097110 [scaffold protein binding]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 150 aa
17.6 kDa 		Yes 0
TREM1-003
ENSP00000465345
ENST00000591620
Q9NP99 [Direct mapping]
Triggering receptor expressed on myeloid cells 1
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006959 [humoral immune response]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
GO:0045087 [innate immune response]
GO:0050776 [regulation of immune response]
GO:0050900 [leukocyte migration]
GO:0097110 [scaffold protein binding]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 225 aa
25.6 kDa 		Yes 0
TREM1-007
ENSP00000465688
ENST00000589614
K7EKM5 [Direct mapping]
Triggering receptor expressed on myeloid cells 1, isoform CRA_b; Triggering receptor-expressed on myeloid cells 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005515 [protein binding]
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 250 aa
28.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.