Expression of GLO1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GLO1
Gene description	Glyoxalase I
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, highly abundant in Leydig cells and in in prostate, epididymis and thyroid glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.
Reliability score	Supported based on 2 antibodies. CAB040541 , CAB040542
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB040541	CAB040542

GENE INFORMATION
Gene name	GLO1 (HGNC Symbol)
Synonyms	GLOD1
Description	Glyoxalase I (HGNC Symbol)
Entrez gene summary	The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	38675925 - 38703141
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124767 (version 83.38)
Entrez gene	2739
UniProt	Q04760 (UniProt - Evidence at protein level)
neXtProt	NX_Q04760
Antibodypedia	GLO1 antibodies

PROTEIN BROWSER

GLO1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLO1-001 ENSP00000362463 ENST00000373365	Q04760 [Direct mapping] Lactoylglutathione lyase X5DNM4 [Target identity:100%; Query identity:100%] Lactoylglutathione lyase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004462 [lactoylglutathione lyase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006749 [glutathione metabolic process] GO:0008270 [zinc ion binding] GO:0009438 [methylglyoxal metabolic process] GO:0030316 [osteoclast differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	184 aa 20.8 kDa	No	0