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GLO1

GENERAL INFORMATION

Gene name

 GLO1

Gene description

 Glyoxalase I

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, highly abundant in Leydig cells and in in prostate, epididymis and thyroid glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
CAB040541 , CAB040542
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GLO1 (HGNC Symbol)

Synonyms

 GLOD1

Description

 Glyoxalase I (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.2

Chromosome location (bp)

 38675925 - 38703141

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124767 (version 83.38)

Entrez gene

 2739

UniProt

 Q04760 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04760

Antibodypedia

 GLO1 antibodies

PROTEIN BROWSER
GLO1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLO1-001
ENSP00000362463
ENST00000373365
Q04760 [Direct mapping]
Lactoylglutathione lyase
X5DNM4 [Target identity:100%; Query identity:100%]
Lactoylglutathione lyase
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004462 [lactoylglutathione lyase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006749 [glutathione metabolic process]
GO:0008270 [zinc ion binding]
GO:0009438 [methylglyoxal metabolic process]
GO:0030316 [osteoclast differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 184 aa
20.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.