Expression of RPP40 in cancer - Summary - The Human Protein Atlas

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RPP40

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPP40
Gene description	Ribonuclease P/MRP 40kDa subunit
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035685 , HPA035686
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035685	HPA035686

Cancer	Cancer staining
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	A majority of cancers displayed weak to moderate cytoplasmic positivity. Few cases of stomach cancers were strongly stained. Many cases of gliomas, lymphomas and renal cancers were negative.

GENE INFORMATION
Gene name	RPP40 (HGNC Symbol)
Synonyms	bA428J1.3, RNASEP1
Description	Ribonuclease P/MRP 40kDa subunit (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p25.1
Chromosome location (bp)	4994732 - 5004063
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124787 (version 83.38)
Entrez gene	10799
UniProt	O75818 (UniProt - Evidence at protein level)
neXtProt	NX_O75818
Antibodypedia	RPP40 antibodies

PROTEIN BROWSER

RPP40-001	RPP40-002	RPP40-006	RPP40-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPP40-001 ENSP00000369391 ENST00000380051	O75818 [Direct mapping] Ribonuclease P protein subunit p40 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004526 [ribonuclease P activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005655 [nucleolar ribonuclease P complex] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0090501 [RNA phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	363 aa 41.8 kDa	No	0
RPP40-002 ENSP00000317998 ENST00000319533	O75818 [Direct mapping] Ribonuclease P protein subunit p40 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004526 [ribonuclease P activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005655 [nucleolar ribonuclease P complex] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0090501 [RNA phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	340 aa 39.3 kDa	No	0
RPP40-006 ENSP00000419431 ENST00000464646	X6RLL4 [Direct mapping] Ribonuclease P protein subunit p40 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		303 aa 34.7 kDa	No	0
RPP40-201 ENSP00000484334 ENST00000618533	A0A087X1N3 [Direct mapping] Ribonuclease P 40kDa subunit, isoform CRA_c; Ribonuclease P protein subunit p40 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		321 aa 36.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.