Expression of EEF1E1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

EEF1E1

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EEF1E1
Gene description	Eukaryotic translation elongation factor 1 epsilon 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA027901
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (favourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Cervical cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027901

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer cells displayed moderate to strong cytoplasmic immunoreactivity. Strongest staining was observed in endometrial and colorectal cancers.

GENE INFORMATION
Gene name	EEF1E1 (HGNC Symbol)
Synonyms	AIMP3, P18
Description	Eukaryotic translation elongation factor 1 epsilon 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Chromosome	6
Cytoband	p24.3
Chromosome location (bp)	8073360 - 8102578
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124802 (version 83.38)
Entrez gene	9521
UniProt	O43324 (UniProt - Evidence at protein level)
neXtProt	NX_O43324
Antibodypedia	EEF1E1 antibodies

PROTEIN BROWSER

EEF1E1-001	EEF1E1-002	EEF1E1-003	EEF1E1-004	EEF1E1-005	EEF1E1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EEF1E1-001 ENSP00000425577 ENST00000488226	D6RCQ0 [Direct mapping] Eukaryotic translation elongation factor 1 epsilon-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.4 kDa	No	0
EEF1E1-002 ENSP00000369038 ENST00000379715	O43324 [Direct mapping] Eukaryotic translation elongation factor 1 epsilon-1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006414 [translational elongation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006749 [glutathione metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0043065 [positive regulation of apoptotic process] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0070062 [extracellular exosome] Show all	174 aa 19.8 kDa	No	0
EEF1E1-003 ENSP00000424222 ENST00000507463	D6RBD7 [Direct mapping] Eukaryotic translation elongation factor 1 epsilon-1; HCG15559, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	150 aa 16.7 kDa	No	1
EEF1E1-004 ENSP00000414363 ENST00000429723	O43324 [Direct mapping] Eukaryotic translation elongation factor 1 epsilon-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006414 [translational elongation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006749 [glutathione metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0043065 [positive regulation of apoptotic process] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0070062 [extracellular exosome] Show all	139 aa 15.5 kDa	No	1
EEF1E1-005 ENSP00000427572 ENST00000502429	H0YAL7 [Direct mapping] Eukaryotic translation elongation factor 1 epsilon-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.2 kDa	No	0
EEF1E1-006 ENSP00000427143 ENST00000515633	H0YAH9 [Direct mapping] Eukaryotic translation elongation factor 1 epsilon-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 5.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.