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Rare case of lung, skin and urothelial cancer displayed strong nuclear staining. Moderate positivity was observed in a case of non Hodgkins lymphoma. Remaining cancer tissues were weakly stained or negative.
Several cases of endometrial, cervical, ovarian and urothelial cancers displayed moderate to strong nuclear staining with additional cytoplasmic and/or membranous positivity in a few cases. Rare cases of lymphomas, melanomas and thyroid were moderately stained. Remaining cancer tissues were weakly stained or negative.
Few cases of melanomas, lymphomas, renal and urothelial cancers showed moderate nuclear positivity. Few ovarian and endometrial cancers exhibited moderate to strong membranous staining. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
RUNX2 (HGNC Symbol)
Synonyms
AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1
Description
Runt-related transcription factor 2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]