Expression of CLYBL in cancer - Summary - The Human Protein Atlas

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CLYBL

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLYBL
Gene description	Citrate lyase beta like
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA039959 , HPA040691
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039959	HPA040691

GENE INFORMATION
Gene name	CLYBL (HGNC Symbol)
Synonyms	CLB
Description	Citrate lyase beta like (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	99606669 - 99897134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125246 (version 83.38)
Entrez gene	171425
UniProt	Q8N0X4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N0X4
Antibodypedia	CLYBL antibodies

PROTEIN BROWSER

CLYBL-001	CLYBL-002	CLYBL-003	CLYBL-004	CLYBL-005	CLYBL-006	CLYBL-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLYBL-001 ENSP00000365533 ENST00000376355	Q8N0X4 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003824 [catalytic activity] GO:0004474 [malate synthase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] Show all	340 aa 37.4 kDa	No	0
CLYBL-002 ENSP00000365532 ENST00000376354	Q8N0X4 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003824 [catalytic activity] GO:0004474 [malate synthase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] Show all	306 aa 33.4 kDa	No	0
CLYBL-003 ENSP00000342991 ENST00000339105	Q8N0X4 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003824 [catalytic activity] GO:0004474 [malate synthase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] Show all	340 aa 37.4 kDa	No	0
CLYBL-004 ENSP00000403408 ENST00000416504	Q5JVC2 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	181 aa 20.2 kDa	No	1
CLYBL-005 ENSP00000401586 ENST00000443887	Q5JVC1 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	147 aa 16.3 kDa	No	1
CLYBL-006 ENSP00000389062 ENST00000425186	Q5JVB9 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10 kDa	No	0
CLYBL-007 ENSP00000396574 ENST00000419700	Q5JVC0 [Direct mapping] Citrate lyase subunit beta-like protein, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	103 aa 11.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.