Cell atlas - ABCC4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ABCC4

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Plasma membrane

Human cell
	Cytosol
	Nucleoli
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ABCC4
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli, plasma membrane & cytosol.
RNA cell category	Group enriched (HMC-1, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002476
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli, plasma membrane & cytosol.

Main location

Nucleoli (approved), Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002476	A-431	Nucleoli
	HPA002476	A-431	Plasma membrane
	HPA002476	U-2 OS	Nucleoli
	HPA002476	U-2 OS	Cytosol
	HPA002476	U-251 MG	Nucleoli
	HPA002476	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ABCC4 (HGNC Symbol)
Synonyms	EST170205, MOAT-B, MOATB, MRP4
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Chromosome	13
Cytoband	q32.1
Chromosome location (bp)	95019829 - 95301446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125257 (version 83.38)
Entrez gene	10257
UniProt	O15439 (UniProt - Evidence at protein level)
neXtProt	NX_O15439
Antibodypedia	ABCC4 antibodies

PROTEIN BROWSER

ABCC4-001	ABCC4-006	ABCC4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC4-001 ENSP00000366084 ENST00000376887	O15439 [Direct mapping] Multidrug resistance-associated protein 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007596 [blood coagulation] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity] GO:0016887 [ATPase activity] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] Show all	1325 aa 149.5 kDa	No	>9
ABCC4-006 ENSP00000442024 ENST00000536256	O15439 [Direct mapping] Multidrug resistance-associated protein 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007596 [blood coagulation] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity] GO:0016887 [ATPase activity] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] Show all	784 aa 88.1 kDa	No	6
ABCC4-007 ENSP00000487081 ENST00000629385	O15439 [Direct mapping] Multidrug resistance-associated protein 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007596 [blood coagulation] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity] GO:0016887 [ATPase activity] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] Show all	859 aa 96.8 kDa	No	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.