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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABCC4
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCC4

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Protein class

Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Group enriched (HEL, HMC-1)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in prostate glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA002476
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY

HPA002476

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues were negative. A few testis and prostate cancers displayed weak cytoplasmic and membranous staining.

GENE INFORMATION

Gene name

ABCC4 (HGNC Symbol)

Synonyms

EST170205, MOAT-B, MOATB, MRP4

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

13

Cytoband

q32.1

Chromosome location (bp)

95019829 - 95301446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125257 (version 83.38)

Entrez gene

10257

UniProt

O15439 (UniProt - Evidence at protein level)

neXtProt

NX_O15439

Antibodypedia

ABCC4 antibodies

PROTEIN BROWSER

ABCC4-001
ABCC4-006
ABCC4-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC4-001
ENSP00000366084
ENST00000376887
O15439 [Direct mapping]
Multidrug resistance-associated protein 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016887 [ATPase activity]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
Show all
1325 aa
149.5 kDa
No >9
ABCC4-006
ENSP00000442024
ENST00000536256
O15439 [Direct mapping]
Multidrug resistance-associated protein 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016887 [ATPase activity]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
Show all
784 aa
88.1 kDa
No 6
ABCC4-007
ENSP00000487081
ENST00000629385
O15439 [Direct mapping]
Multidrug resistance-associated protein 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016887 [ATPase activity]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
Show all
859 aa
96.8 kDa
No 9

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