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ABCC4

GENERAL INFORMATION

Gene name

 ABCC4

Gene description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Protein class

 Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Group enriched (HEL, HMC-1)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in prostate glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA002476
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA002476

GENE INFORMATION

Gene name

 ABCC4 (HGNC Symbol)

Synonyms

 EST170205, MOAT-B, MOATB, MRP4

Description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

 13

Cytoband

 q32.1

Chromosome location (bp)

 95019829 - 95301446

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125257 (version 83.38)

Entrez gene

 10257

UniProt

 O15439 (UniProt - Evidence at protein level)

neXtProt

 NX_O15439

Antibodypedia

 ABCC4 antibodies

PROTEIN BROWSER
ABCC4-001
ABCC4-006
ABCC4-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCC4-001
ENSP00000366084
ENST00000376887
O15439 [Direct mapping]
Multidrug resistance-associated protein 4
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016887 [ATPase activity]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
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 1325 aa
149.5 kDa 		No >9
ABCC4-006
ENSP00000442024
ENST00000536256
O15439 [Direct mapping]
Multidrug resistance-associated protein 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016887 [ATPase activity]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
Show all
 784 aa
88.1 kDa 		No 6
ABCC4-007
ENSP00000487081
ENST00000629385
O15439 [Direct mapping]
Multidrug resistance-associated protein 4
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016887 [ATPase activity]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
Show all
 859 aa
96.8 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.