Cell atlas - PTGER2 - The Human Protein Atlas

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PTGER2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PTGER2
Gene description	Prostaglandin E receptor 2 (subtype EP2), 53kDa
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (ASC TERT1, SH-SY5Y, HL-60)
Protein evidence	Evidence at transcript level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, SH-SY5Y, HL-60) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PTGER2 (HGNC Symbol)
Synonyms	EP2
Description	Prostaglandin E receptor 2 (subtype EP2), 53kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
Chromosome	14
Cytoband	q22.1
Chromosome location (bp)	52314305 - 52328606
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000125384 (version 83.38)
Entrez gene	5732
UniProt	P43116 (UniProt - Evidence at transcript level)
neXtProt	NX_P43116
Antibodypedia	PTGER2 antibodies

PROTEIN BROWSER

PTGER2-001	PTGER2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGER2-001 ENSP00000245457 ENST00000245457	P43116 [Direct mapping] Prostaglandin E2 receptor EP2 subtype Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004957 [prostaglandin E receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032496 [response to lipopolysaccharide] GO:0032570 [response to progesterone] GO:0042127 [regulation of cell proliferation] GO:0071380 [cellular response to prostaglandin E stimulus] Show all	358 aa 39.8 kDa	No	7
PTGER2-002 ENSP00000450933 ENST00000557436	G3V2Y6 [Direct mapping] Prostaglandin E2 receptor EP2 subtype Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004957 [prostaglandin E receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	103 aa 11.7 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.