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PTGER2

GENERAL INFORMATION

Gene name

 PTGER2

Gene description

 Prostaglandin E receptor 2 (subtype EP2), 53kDa

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (ASC TERT1, HL-60, SH-SY5Y)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PTGER2 (HGNC Symbol)

Synonyms

 EP2

Description

 Prostaglandin E receptor 2 (subtype EP2), 53kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

Chromosome

 14

Cytoband

 q22.1

Chromosome location (bp)

 52314305 - 52328606

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000125384 (version 83.38)

Entrez gene

 5732

UniProt

 P43116 (UniProt - Evidence at transcript level)

neXtProt

 NX_P43116

Antibodypedia

 PTGER2 antibodies

PROTEIN BROWSER
PTGER2-001
PTGER2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGER2-001
ENSP00000245457
ENST00000245457
P43116 [Direct mapping]
Prostaglandin E2 receptor EP2 subtype
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0032570 [response to progesterone]
GO:0042127 [regulation of cell proliferation]
GO:0071380 [cellular response to prostaglandin E stimulus]
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 358 aa
39.8 kDa 		No 7
PTGER2-002
ENSP00000450933
ENST00000557436
G3V2Y6 [Direct mapping]
Prostaglandin E2 receptor EP2 subtype
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
 103 aa
11.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.