Expression of BHLHE23 in cancer - Summary - The Human Protein Atlas

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BHLHE23

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BHLHE23
Gene description	Basic helix-loop-helix family, member e23
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	No RNA expression data detected and pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA030575
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030575

GENE INFORMATION
Gene name	BHLHE23 (HGNC Symbol)
Synonyms	bA305P22.3, Beta4, BHLHB4, bHLHe23
Description	Basic helix-loop-helix family, member e23 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	63005927 - 63007035
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000125533 (version 83.38)
Entrez gene	128408
UniProt	Q8NDY6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NDY6
Antibodypedia	BHLHE23 antibodies

PROTEIN BROWSER

BHLHE23-001	BHLHE23-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BHLHE23-001 ENSP00000480998 ENST00000612929	A0A087WXG3 [Direct mapping] Class E basic helix-loop-helix protein 23 Show all	Predicted intracellular proteins Show all	GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046548 [retinal rod cell development] GO:0046671 [negative regulation of retinal cell programmed cell death] GO:0046983 [protein dimerization activity] GO:0048050 [post-embryonic eye morphogenesis] Show all	241 aa 25.2 kDa	No	0
BHLHE23-201 ENSP00000359371 ENST00000370346	Q8NDY6 [Direct mapping] Class E basic helix-loop-helix protein 23 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	225 aa 23.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.